Erratum for Mandelbrot et al., placental transfer of rilpivirine in an ex vivo human cotyledon perfusion model.
نویسندگان
چکیده
Laurent Mandelbrot, Dominique Duro, Emilie Belissa, Gilles Peytavin Assistance Publique-Hôpitaux de Paris, Hôpital Louis Mourier, Service de Gynécologie-Obstétrique, Hôpitaux Universitaires Paris-Nord Val de Seine, Colombes, France; Université Paris-Diderot, Université Sorbonne Paris-Cité, DHU Risks in Pregnancy, Paris, France; INSERM U1018, Kremlin-Bicêtre, France; Assistance Publique-Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Clinical Pharmaco-Toxicology Department, Hôpitaux Universitaires Paris-Nord Val de Seine, Paris, France; IAME, UMR 1137, INSERM, Paris, France
منابع مشابه
Placental transfer of rilpivirine in an ex vivo human cotyledon perfusion model.
Placental transfers of the HIV nonnucleoside reverse transcriptase inhibitor rilpivirine were investigated in 8 term human cotyledons perfused with rilpivirine (400 ng/ml) in the maternal-to-fetal direction. The mean fetal transfer rate (FTR) (fetal/maternal concentration at steady state from 15 to 90 min) was 26% ± 8% (mean ± standard deviation), and the clearance index (rilpivirine FTR/antipy...
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Placental transfer of the HIV protease inhibitor darunavir was investigated in 5 term human cotyledons perfused with darunavir (1,000 ng/ml) in the maternal to fetal direction. The mean (± the standard deviation [SD]) fetal transfer rate (FTR) (fetal/maternal concentration at steady state from 30 to 90 min) was 15.0%±2.1%, and the mean (±SD) clearance index (darunavir FTR/antipyrine FTR) was 40...
متن کاملDetermination of the transport rate of xenobiotics and nanomaterials across the placenta using the ex vivo human placental perfusion model.
Decades ago the human placenta was thought to be an impenetrable barrier between mother and unborn child. However, the discovery of thalidomide-induced birth defects and many later studies afterwards proved the opposite. Today several harmful xenobiotics like nicotine, heroin, methadone or drugs as well as environmental pollutants were described to overcome this barrier. With the growing use of...
متن کاملPlacental transfer of maraviroc in an ex vivo human cotyledon perfusion model and influence of ABC transporter expression.
Nowadays, antiretroviral therapy is recommended during pregnancy to prevent mother-to-child transmission of HIV. However, for many antiretroviral drugs, including maraviroc, a CCR5 antagonist, very little data exist regarding placental transfer. Besides, various factors may modulate this transfer, including efflux transporters belonging to the ATP-binding cassette (ABC) transporter superfamily....
متن کاملTransfer of meropenem in the ex vivo human placenta perfusion model.
OBJECTIVES To determine maternal-fetal transplacental passage of meropenem in the ex vivo human perfusion model. STUDY DESIGN Term placentae (n = 6) were collected immediately after delivery. A single cotyledon was localized, perfused and stabilized with physiologic Eagles minimal essential medium containing 3% bovine albumin and heparin as described by Chalier (Chalier JC. Criteria for evalu...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 59 9 شماره
صفحات -
تاریخ انتشار 2015